I worry about LSPI (Low Speed Pre-Ignition) which is very bad for pistons/rings/plugs etc. and is a function of octane and oil vapors. I don't think timing is much of a factor. So I run 93 octane which is the highest I can find around here.
This is pretty good explanation of LSPI:
https://www.valvolineglobal.com/en-eur/what-is-lspi/