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03-10-2014, 09:41 PM | #133 | |
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03-10-2014, 09:48 PM | #134 | |
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03-10-2014, 09:49 PM | #135 |
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I will never own one, but I won't fly off the handle if someone has a replica. However, I did get a little angry when my brother in law asked how much I paid for my Rolex Explorer II when he paid $150 for a fake Explorer II. However, a few months later, it broke on him. To some extent, you do get what you pay for.
If I were you, I would get an homage watch as opposed to a replica. It will look like the real deal up to about a foot away, then if a watch snob asks, you won't have to deal with a diatribe about how wrong it is to wear a fake. The best quality homages out there are from Alpha. A lot of guys on the watch forums love Alpha. It's a great starter watch too for people who aren't into automatic watches and don't want to blow a grand on something new. http://www.alpha-watch.com/
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03-10-2014, 09:52 PM | #136 | |
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03-10-2014, 09:56 PM | #137 | |
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Pharmaceutical companies are highly regulated by the FDA and for good reason. Even subtle differences in the manufacturing process can lead to disastrous side effects for the patient, and so a lot of the cost of drugs goes into "over-engineering" (for lack of a better term) the final product. Purification, for example, is not a trivial process. A lot of people probably take it for granted but that's one area (among many) where the process can be "over-engineered" in the pursuit of higher selectivity. |
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03-10-2014, 10:01 PM | #138 | |
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03-10-2014, 10:13 PM | #139 | |
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03-10-2014, 10:24 PM | #140 | |
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03-10-2014, 11:34 PM | #142 | |
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03-11-2014, 02:21 AM | #143 |
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Fakes are for people to pretend. Kind of like a fantasy novel or daydreaming. It does serve this purpose.
Generics and pirated software is different, where the value is in the unpaid use of IP protected design. Ain't nobody going to say it's right to stop generics being used in Africa to save people from aids.. Windows can cost a month's salary for people in developing countries - I don't think Bill Gates could sleep at night if he were to pursue these people for $$ just so he can get into the $100Bs. That said, fakes for show is a side show.. the luxury companies pursue it to the extent it's in their interest, knowing it also helps to promote the brand so that even if 1 in 100 of these fake buyers were to have money one day to buy the real, they would still make money. Besides this, bashing fake manufacturors, buyers, *ahem* China - we all have our go-to whipping boys .. what is less clear is the psychological mechanism behind this. |
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03-11-2014, 04:33 AM | #144 |
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What is weird is paying say $9000 (out of the Ł10k cost price) just to have Rolex painted on the watch face. It doesn't tell the time any better, they are nice enough looking watches but there are plenty of good looking watches to choose from that are just as well made, reliable and sensibly priced. It would grieve me too much to buy any designer item (not just watches) knowing that so little of the cost goes on the actual item itself. I guess if you are into watches it must make sense, God knows I've blown enough money on cars over the years.
Last edited by SenorFunkyPants; 03-11-2014 at 04:53 AM.. |
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03-11-2014, 01:24 PM | #145 | |
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Generic pharmaceuticals are equivalent to brand products for all its active properties, forms, dosages etc. and it is highly regulated. No one buys the brand product after the generic is available! I'm not a pharmacist so I can't speak to the actual differences between drugs. We are way off topic...
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03-11-2014, 02:06 PM | #146 | ||
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Generic manufacturers are immune to liability because it's assumed it's the same as the branded counterpart when it's not. The only reason generic sales continue to be relevant is because of health insurance and formularies. Formulary or not, I only buy branded drugs and my scripts are DAW branded for my own health and well-being. Generic drugs are not the same thing and there is plenty of objective research done to prove it. |
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03-11-2014, 02:30 PM | #147 | |
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Of course generics are needed. The costs are much less than the branded drugs. Customers save money in getting the same products. And in the case of "authorized generics", they are even made by the same companies who make the branded product and is essentially the same product!
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03-11-2014, 03:23 PM | #148 | |
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03-11-2014, 07:25 PM | #149 | |
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From the same page you quote: "Generics are not required to replicate the extensive clinical trials that have already been used in the development of the original, brand-name drug. These tests usually involve a few hundred to a few thousand patients. Since the safety and efficacy of the brand-name product has already been well established in clinical testing and frequently many years of patient use, it is scientifically unnecessary, and would be unethical, to require that such extensive testing be repeated in human subjects for each generic drug that a firm wishes to market. Instead, generic applicants must scientifically demonstrate that their product is bioequivalent (i.e., performs in the same manner) to the pioneer drug." So they are the same? Here's what a 2 second search on NCBI provided (click the link to read the abstract): Few publications compared the bioequivalence and efficacy of brand-name and generic psychoactive drugs. Those that were identified revealed differences in the efficacy and tolerability of brand-name and generic psychoactive drugs that had not been noted in the original bioequivalence studies. There were no significant differences in overall tolerance (GSRS) between treatment groups. However, for subscale abdominal pain, patients using generic had a significantly higher mean GSRS score at week 4 To conclude... the patient had a fainting spell in his apartment, after which his blood pressure was found to be 220/120 mm Hg. Medication compliance did not appear to be an issue, but the same “family” physician realized that the patient had been switched to a generic ($30.25/mo v. $36.56/mo for the brand medication). The original brand was immediately restored, and 2 days later blood pressure was back down to 150/90 mm Hg. My father subsequently died from a dissected aorta, a well-known complication of high blood pressure. |
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03-11-2014, 07:31 PM | #151 |
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What do you think bioequivalence means? If the same chemical compound is available at the same rate and amount failure of treatment has nothing to do with the product used.
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03-11-2014, 07:33 PM | #152 | |
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Yeah, I abuse my Z-paks and hawk them on the street for those who have bronchitis. Unfortunately, the FDA requirement for generics will soon blow up in their face as it has for many other fast-tracked approvals. Teva, the largest generic manufacturer in the world has a significant;y lower market share in their home country of Israel in comparison to the US. Do you know why? Here's a hint: It's not because of formulary issues |
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03-11-2014, 07:55 PM | #153 |
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Yes there is no difference, not a belief. If you start talking about counterfeit and unregulated drugs coming out of other countries they could be suspect. It is a chemical compound, if it has that in it and is bioevquivalent, what is required, yes it is the same. You give me 100 percent pure cocaine or any other compound it doesn't matter what name you call it if its measured out to the same amount it does the same thing. Any variation in reaction is due to individual personal variance.
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03-11-2014, 07:56 PM | #154 | |
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The active ingredient in two different toothpastes may be sodium fluoride but for some reason, my mouth feels cleaner using one toothpaste over another. |
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